HealthcareStudy shows important change in B-cells in women with...

Study shows important change in B-cells in women with PPD


B cell , B lymphocyte
3D rendering of a B cell. Credit: Blausen.com staff (2014). “Medical gallery of Blausen Medical 2014”. WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. CC BY-SA 4.0

A study published in Molecular Psychiatry is the first to look at multiple levels of biology within women with postpartum depression (PPD) to see how women with the condition differ from those without it. PPD affects 1 in 7 women and has negative mental health consequences for both mother and child. However, the precise biological mechanisms behind the disorder are unknown.

“We don’t have PPD figured out,” said lead author Jerry Guintivano, Ph.D., assistant professor in the UNC Department of Psychiatry. “A lot of biological research focuses on candidate genes and hormones, and we do have a lead on some PPD-specific medications, but it’s important to take multiple avenues to target this condition. Not every manifestation of PPD is the same.”

That’s why Guintivano led a team of researchers from the UNC School of Medicine to conduct the largest transcriptome-wide association study for PPD to date. Previous studies have only analyzed whole blood samples. This study took a deeper look and examined the different components of blood. They took blood samples from 1,500 racially and ethnically diverse from across North Carolina who had given birth within the past six weeks, 482 of whom were diagnosed with PPD. Researchers used RNA sequencing, DNA genotyping, and assessment of DNA methylation—amounting to three levels of basic biology evaluation—to look for differences in components of the from women with PPD versus women without PPD.

They found that B-cells had significant differences in women with PPD. B-cells are an important part of the immune system. They become activated when their receptor recognizes an antigen and binds to it. Activated B-cells then produce antibodies, and also secrete pro- and anti-inflammatory factors.

“There’s a really delicate interplay of the immune system during pregnancy,” Guintivano said. “It has to prevent infection from a cold, and it also has to finely tune itself so it doesn’t recognize the fetus as a foreign body and attack it. Then in the postpartum period, all these hormones and pathways reset to get back to pre-pregnancy.”

In women with PPD, the UNC researchers found thousands of individual B-cell transcripts that were different from women without PPD, regulated in part by genetic variants and DNA methylation. To confirm those findings they conducted pathway analysis, which implicated altered B-cell activation and .

“This is really just the first step in a long line of research that now needs to be done,” Guintivano said. “This is the biggest study of its type but we still don’t know why B-cells are changing. Are they reflecting another change in the body that is caused by or causes PPD? What is driving this B-cell behavior?”

Guintivano says their next step is to conduct a that tracks women across a longer period of time to see how B-cells change through pregnancy and into the postpartum period. He says none of this research would be possible without many women being dedicated to research on PPD.

“The women who participated in this study are new moms who came in during a very critical time when their babies are weeks old to participate in research to help other women, Guintivano said. “I want to thank them for that. We want to do their contributions justice with our research.”


Postpartum trajectory differs by race after hypertensive disorders of pregnancy


More information:
Jerry Guintivano et al, Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance, Molecular Psychiatry (2022). DOI: 10.1038/s41380-022-01525-7

Citation:
Study shows important change in B-cells in women with PPD (2022, April 8)
retrieved 9 April 2022
from https://medicalxpress.com/news/2022-04-important-b-cells-women-ppd.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.





Original Source Link

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Latest News

The World’s Largest Real Estate Companies In 2022

One Manhattan West near Hudson Yards in New York is one...

Finland Wants To Join NATO. Why Is It Considering Membership?

Sweden is still weighing up the prospect of NATO membership while its neighbor Finland has already announced it...

Here’s How To Watch The Star Trek: Strange New Worlds Series Premiere For Free Right Now

With due respect to all the other 21st century "Trek" shows, "Strange New Worlds" is the one you...

Bitcoin (BTC) price falls below $27,000 as crypto sell-off intensifies

Bitcoin plunged further below the $30,000 mark as investors fled cryptocurrencies.Jaap Arriens | NurPhoto | Getty ImagesBitcoin slumped...

Reminder: Withdraw Your Bitcoin Off Exchanges

The below is a direct excerpt of Marty's Bent Issue #1207: “Reminder to get your bitcoin off the...

UK economy shrinks in March as manufacturing and services falter

The UK economy contracted in March, continuing the poor performance of the previous month as manufacturing slowed and...

Must Read

Bank of England warns of UK recession this year as it lifts interest rate

The Bank of England has warned that the...

Doctors Without Borders addresses charges of racism within its ranks

Journalists have compiled instances of favoring international staff...
- Advertisement -

You might also likeRELATED
Recommended to you