HealthcareEvaluate report signals orphan drug market is niche no...

Evaluate report signals orphan drug market is niche no more


London, UK – 28 April 2022Evaluate, the leading provider of market intelligence and predictive analytics for the pharmaceutical industry, has today released the findings of its 2022 Orphan Drug Report.

Evaluate’s data shows that the orphan drug market is growing more than twice as fast as the non-orphan pharmaceuticals market, with 2021-2026 CAGR topping 12%. By 2026 orphan drug sales will account for 20% of all prescription drug sales and almost a third of the global drug pipeline’s value. Each of the top ten orphan blockbusters in 2026 will be worth between $3 billion and $13 billion and look set to out-size mass market drugs.

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Big pharma’s increasing reliance on orphan drugs for sales is anticipated to continue, with nine of the top-ten best-selling orphan drugs in 2026 expected to be marketed or co-marketed by big pharma. Over a fifth of sales at eight big pharma will also be from orphans. Four blood cancer drugs will account for about half of the $65 billion combined sales from 2026’s top ten orphans.

Paul Verdin, VP Consulting and Analytics at Evaluate said: “The orphan drug sector continues to experience rapid growth. Over half of the FDA’s approvals in 2021 were assigned to orphan drugs intended to treat rare diseases, a development that signals that orphan drugs should no longer be regarded as niche products.

“Orphans’ strong growth is leading to crowding in some corners of the market, but many of the estimated 7,000 rare diseases remain under-served, so the opportunity for further investment and R&D is high. As other diseases are better understood and sliced into narrower sub-categories, they are more likely to meet the criteria for a rare condition,” he added.

The report notes that the rise of orphan drug blockbusters may drive calls to reform the 40 year old US Orphan Drug Act and the European Union’s 1999 Orphan Regulation to temper prices. While this may result in changes to reimbursement, especially in Europe’s biggest market, Germany, the orphan drug market shows no sign of losing momentum.

The pharma R&D pipeline is currently packed with next-generation CAR-T cell therapies, gene therapies, targeted cancer drugs and other new modalities – many with orphan designations. The net present value of forecast 2026 sales of the top ten pipeline orphan drugs is more than $42 billion.

Read the 2022 Evaluate Orphan Drug Report in full here: https://www.evaluate.com/thought-leadership/pharma/orphan-drug-2022-report?utm_source=PR&utm_medium=PR&utm_campaign=Orphan_Drug_2022

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About Evaluate Ltd
Since 1996, Evaluate has provided the life sciences industry with the data, insight and intelligence to facilitate confident decision making on high-value investments in treatments and markets. We enable our clients to embed our proprietary & industry data into their workflows, tools and processes so they can work more effectively and efficiently. For more information about Evaluate, visit www.evaluate.com and follow us on LinkedIn and Twitter.

For media inquiries, please contact:
media@evaluate.com





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