HealthcareReal-world data links rosuvastatin with signs of kidney damage

Real-world data links rosuvastatin with signs of kidney damage


Real-world data links rosuvastatin with signs of kidney damage
Graphical abstract. Credit: Journal of the American Society of Nephrology (2022). DOI: 10.1681/ASN.2022020135

Statins can effectively lower high cholesterol, and many individuals take rosuvastatin, one member of this drug class. New research based on patient health records and published in Journal of the American Society of Nephrology suggests that rosuvastatin, especially at higher doses, may have damaging effects on the kidneys.

Reports had linked rosuvastatin with signs of kidney damageโ€”hematuria (blood in the urine) and proteinuria (protein in the urine)โ€”at the time of its approval by the U.S. Food and Drug Administration, but little post-marketing surveillance exists to assess real-world risk. To investigate, Jung-Im Shin, MD, Ph.D. (Johns Hopkins Bloomberg School of Public Health) and her colleagues analyzed electronic health record data for 152,101 new users of rosuvastatin and 795,799 new users of another statin called atorvastatin from 2011โ€“2019.

Over a median follow-up of 3.1 years, the team identified hematuria in 2.9% of patients and proteinuria in 1.0% of patients. Compared with atorvastatin, rosuvastatin was associated with an 8% higher risk of hematuria, a 17% higher risk of proteinuria, and a 15% higher risk of developing requiring replacement therapy such as dialysis or transplantation. Risks of hematuria and proteinuria were higher with a higher dose of rosuvastatin. Also, among patients with advanced kidney disease, 44% were prescribed a higher dose of rosuvastatin than the US Food and Drug Administration recommends for individuals with poor kidney function.

โ€œWe observed a higher risk of hematuria, proteinuria, as well as kidney failure with rosuvastatin use and similar cardiovascular benefits between the rosuvastatin and atorvastatin groups,โ€ said Dr. Shin. โ€œBecause rosuvastatin may cause proteinuria and hematuria, especially with high dose, high dose rosuvastatin may not merit the riskโ€”even if smallโ€”particularly for patients with advanced kidney disease.โ€


LDL reduction in hypertriglyceridemia varies per statin


More information:
Jung-Im Shin et al, Association of Rosuvastatin Use with Risk of Hematuria and Proteinuria, Journal of the American Society of Nephrology (2022). DOI: 10.1681/ASN.2022020135

Citation:
Real-world data links rosuvastatin with signs of kidney damage (2022, July 19)
retrieved 20 July 2022
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